Kazuhisa Takahashi Selected Research

Intervertebral Disc Degeneration

4/2018	Evaluation of Lumbar Intervertebral Disc Degeneration Using T1ρ and T2 Magnetic Resonance Imaging in a Rabbit Disc Injury Model.
8/2017	Inhibiting Vascular Endothelial Growth Factor in Injured Intervertebral Discs Attenuates Pain-Related Neuropeptide Expression in Dorsal Root Ganglia in Rats.
6/2017	Correlation among Inflammatory Cytokine Expression Levels, Degree of Disk Degeneration, and Predominant Clinical Symptoms in Patients with Degenerated Intervertebral Discs.
1/2017	Spinal fusion on adolescent idiopathic scoliosis patients with the level of L4 or lower can increase lumbar disc degeneration with sagittal imbalance 35 years after surgery.
8/2016	Dose Optimization for Single Intradiscal Administration of the Tumor Necrosis Factor-α Inhibitor, Etanercept, in Rat Disc Injury Models.
1/2016	Single intradiscal injection of the interleukin-6 receptor antibody tocilizumab provides short-term relief of discogenic low back pain; prospective comparative cohort study.
10/2015	Interleukin-6 and interleukin-6 receptor expression, localization, and involvement in pain-sensing neuron activation in a mouse intervertebral disc injury model.
6/2015	Pathomechanisms of discogenic low back pain in humans and animal models.
7/2014	Increase of nerve growth factor levels in the human herniated intervertebral disc: can annular rupture trigger discogenic back pain?
6/2014	Efficacy of anti-nerve growth factor therapy for discogenic neck pain in rats.

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Kazuhisa Takahashi Research Topics

Disease

119	Pain (Aches) 01/2019 - 04/2002
76	Neoplasms (Cancer) 04/2024 - 04/2002
67	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 03/2024 - 01/2005
44	Low Back Pain (Lumbago) 06/2021 - 04/2004
39	Inflammation (Inflammations) 11/2023 - 04/2002
38	Lung Neoplasms (Lung Cancer) 04/2024 - 02/2006
29	Hyperalgesia 01/2017 - 01/2002
22	Neoplasm Metastasis (Metastasis) 01/2023 - 09/2002
21	Lymphangioleiomyomatosis (Lymphangiomyomatosis) 04/2024 - 01/2008
19	COVID-19 04/2024 - 01/2021
19	Asthma (Bronchial Asthma) 01/2024 - 01/2007
17	Disease Progression 03/2024 - 11/2007
17	Intervertebral Disc Degeneration 04/2018 - 10/2006
16	Infections 12/2024 - 10/2008
16	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2024 - 10/2008
16	Neuralgia (Stump Neuralgia) 01/2021 - 01/2007
14	Chronic Obstructive Pulmonary Disease (COPD) 01/2024 - 12/2012
14	Spinal Cord Injuries (Spinal Cord Injury) 01/2016 - 07/2009
14	Intervertebral Disc Displacement (Herniated Disc) 10/2014 - 09/2004
12	Lung Diseases (Lung Disease) 12/2023 - 09/2006
12	Osteoporosis 01/2018 - 01/2005
11	Hypoxia (Hypoxemia) 10/2020 - 10/2008
11	Spinal Stenosis (Stenosis, Spinal) 06/2020 - 06/2011
10	Dyspnea (Shortness of Breath) 01/2024 - 03/2006
10	Pneumonia (Pneumonitis) 01/2022 - 04/2012
10	Scoliosis 05/2021 - 01/2009
10	Pathologic Constriction (Stenosis) 01/2018 - 01/2007
9	Thymoma (Thymic Carcinoma) 11/2023 - 01/2009
9	Cachexia 02/2023 - 01/2008
8	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2024 - 11/2009
8	Adenocarcinoma of Lung 11/2021 - 01/2015
8	Knee Osteoarthritis 11/2017 - 10/2009
7	Emphysema 01/2024 - 02/2008
7	Adenocarcinoma 01/2021 - 12/2008
7	Idiopathic Pulmonary Fibrosis 01/2021 - 01/2019
7	Back Pain (Backache) 01/2018 - 05/2010
7	Spondylolisthesis 01/2018 - 01/2009
7	Osteoarthritis 01/2017 - 02/2010
7	Ganglion Cysts (Ganglion) 08/2013 - 08/2006
6	Tuberous Sclerosis (Bourneville's Disease) 04/2024 - 12/2011
6	Pulmonary Emphysema 01/2022 - 09/2006
6	Carcinoma (Carcinomatosis) 01/2021 - 02/2006
6	Cysts 01/2021 - 06/2012
6	Hip Osteoarthritis (Coxarthrosis) 12/2020 - 10/2012
6	Spinal Cord Diseases 08/2020 - 03/2012
6	Fibrosis (Cirrhosis) 01/2020 - 10/2009
6	Congenital Abnormalities (Deformity) 01/2018 - 07/2010
6	Wounds and Injuries (Trauma) 12/2016 - 08/2011

Drug/Important Bio-Agent (IBA)

40	CytokinesIBA 02/2023 - 04/2002
34	Biomarkers (Surrogate Marker)IBA 02/2024 - 09/2002
30	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2022 - 05/2004
30	Calcitonin Gene-Related PeptideIBA 10/2018 - 04/2004
25	Nerve Growth Factor (NGF)IBA 10/2018 - 04/2004
23	ErbB Receptors (EGF Receptor)IBA 10/2023 - 05/2011
22	lipoarabinomannan (LAM)IBA 04/2024 - 01/2007
19	Adrenal Cortex Hormones (Corticosteroids)IBA 03/2024 - 10/2006
19	salicylhydroxamic acid (SHAM)IBA 03/2018 - 07/2005
18	Proteins (Proteins, Gene)FDA Link 10/2023 - 02/2006
18	Tyrosine Kinase InhibitorsIBA 06/2022 - 03/2014
17	NeuropeptidesIBA 10/2018 - 10/2009
15	AntibodiesIBA 04/2024 - 09/2006
15	Gefitinib (Iressa)FDA Link 10/2023 - 12/2008
14	Immune Checkpoint InhibitorsIBA 03/2024 - 03/2016
13	SteroidsIBA 01/2024 - 07/2011
12	Interleukin-6 (Interleukin 6)IBA 01/2023 - 05/2011
12	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 04/2002
10	Cisplatin (Platino)FDA LinkGeneric 10/2023 - 01/2009
10	Peptides (Polypeptides)IBA 01/2022 - 08/2005
10	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2016 - 01/2012
10	OsteopontinIBA 04/2011 - 04/2002
8	pembrolizumabIBA 03/2024 - 01/2019
8	Analgesics (Analgesic Drugs)IBA 07/2017 - 01/2012
8	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)IBA 10/2015 - 12/2004
7	LigandsIBA 03/2024 - 01/2014
7	Carboplatin (JM8)FDA LinkGeneric 11/2023 - 01/2004
7	Pemetrexed (MTA)FDA Link 01/2023 - 12/2012
7	SmokeIBA 01/2022 - 09/2006
7	EnzymesIBA 05/2021 - 09/2006
7	Transforming Growth Factors (Transforming Growth Factor)IBA 07/2020 - 11/2012
7	Freund's AdjuvantIBA 03/2017 - 01/2002
6	Bevacizumab (Avastin)FDA Link 01/2024 - 04/2016
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2023 - 01/2004
6	nintedanibIBA 01/2023 - 01/2019
6	B7-H1 AntigenIBA 02/2022 - 06/2020
6	Tumor Biomarkers (Tumor Markers)IBA 01/2022 - 01/2005
6	Phosphotransferases (Kinase)IBA 10/2021 - 12/2010
6	InterleukinsIBA 07/2021 - 01/2007
6	Monoclonal AntibodiesIBA 05/2019 - 09/2006
6	Activating Transcription Factor 3IBA 10/2018 - 08/2008
6	Lidocaine (Xylocaine)FDA LinkGeneric 01/2016 - 08/2006
6	methanesulfonate salt 2-hydroxy-4,4'-diamidinostilbeneIBA 12/2015 - 12/2006

Therapy/Procedure

69	Therapeutics 10/2023 - 10/2006
36	Drug Therapy (Chemotherapy) 01/2024 - 01/2004
15	Pedicle Screws 01/2018 - 01/2005
14	Aftercare (After-Treatment) 01/2023 - 08/2009
14	Decompression 06/2020 - 05/2010
13	Spinal Fusion (Spondylosyndesis) 01/2018 - 03/2010
11	Conservative Treatment 01/2016 - 01/2008
6	Transplantation 01/2016 - 10/2009
6	Osteotomy 01/2016 - 10/2012